Medicine

Advancing ASO therapies coming from development to implementation

.Contending passions.R.S., M.S., H.G. as well as A.A.R. are actually organizers of the 1M1M effort. H.G. and also A.A.R. are board of directors participants and R.S., M.S. and also A.A.R. are actually members of the clinical advising board of N1C. A.A.R. reveals work through LUMC, which possesses patents on exon-skipping innovation, a few of which has been accredited to BioMarin and also subsequently sublicensed to Sarepta. As co-inventor of a few of these licenses, A.A.R. was qualified to a portion of royalties. A.A.R. even more reveals working as impromptu professional for PTC Therapies, Sarepta Rehabs, Regenxbio, Dyne Therapeutics, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Over the last 5 years, A.A.R. additionally performed consulting with for Alpha Anomeric. A.A.R. additionally reports membership of the scientific advisory boards of Eisai, Hybridize Rehabs, Silence Rehabs, Sarepta Therapies, Sapreme and Mitorx. Over the last 5 years, A.A.R. was actually also a clinical board of advisers participant for ProQR. Commission for A.A.R. u00e2 s consulting and urging tasks is paid out to LUMC. In the past 5 years, LUMC additionally obtained audio speaker gratuity coming from PTC Rehabs, Alnylam Netherlands, Italfarmaco and Pfizer and financing for deal study from Sapreme, Eisai, Galapagos, Synaffix and also Alpha Anomeric. Job financing is actually received coming from Sarepta Rehabs and Entrada through unrestricted gives. H.G. has nothing at all to disclose in regard to the subject matters covered in this composition. Before 5 years, he has additionally received consultancy honoraria from UCB. M.S. received consultancy honoraria coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa over the last 5 years, all unassociated to the present composition. R.S. has nothing at all to make known in connection with the topics covered in this particular composition. She has obtained sound speaker and/or working as a consultant honoraria or sponsoring payments from Abbvie, Bial, STADA and also Everpharma before 5 years.